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刘进

电子邮箱：

办公地点：

教育背景：

2006-2010 The University of Hong Kong ， PhD

2003-2005 Sun Yat-sen University ， MSc

1999-2003 Sun Yat-sen University ， Bachelor

背景资料：

2015.1-至今 Peking University

2012.1-2015.1 University of Maryland Center for Environmental Science (USA)

2011.1-2012.1 Arizona State University (USA)

研究领域：

Lipid metabolism

Carotenogenesis

Systems biology and synthetic biology

Algae-based biofuels, bio-products, and bioremediation

荣誉与奖励：

期刊论文：

1. Shi M, Yu L, Shi J, Liu J* (2022) A conserved MYB transcription factor is involved in regulating lipid metabolic pathways for oil biosynthesis in green algae. New Phytologist, 235: 576-594

2. Yang J#, Liu J#, Pan Y, Marechal E, Amato A, Liu M, Gong Y, Li Y, Hu H* (2022) PDAT regulates PE as transient carbon sink alternative to triacylglycerol in Nannochloropsis. Plant Physiology, 189: 1345–1362

3. Bai F, Yu L, Shi J, Li-Beisson Y, Liu J* (2022) Long-chain acyl-CoA synthetases activate fatty acids for lipid synthesis, remodeling and energy production in Chlamydomonas. New Phytologist, 233: 823-837

4. Liu J*, Liu M, Pan Y, Shi Y, Hu H (2022) Metabolic engineering of the oleaginous alga Nannochloropsis for enriching eicosapentaenoic acid in triacylglycerol by combined pulling and pushing strategies. Metabolic Engineering, 69: 163-174

5. Wu T, Yu L, Zhang Y, Liu J* (2021) Characterization of fatty acid desaturases reveals stress-induced synthesis of C18 unsaturated fatty acids enriched in triacylglycerol in the oleaginous alga Chromochloris zofingiensis. Biotechnology for Biofuels, 14:184.

6. Shi Y, Liu M, Pan Y, Hu H, Liu J* (2021) Δ6 Fatty Acid Elongase is Involved in Eicosapentaenoic Acid Biosynthesis Via the ω6 Pathway in the Marine Alga Nannochloropsis oceanica. Journal of Agricultural and Food Chemistry, 69:9837−9848.

7. Bai F, Zhang Y, Liu J* (2021) A bZIP transcription factor is involved in regulating lipid and pigment metabolisms in the green alga Chlamydomonas reinhardtii. Algal Research 59:102450.

8. Zhang Y, Ye Y, Bai F, Liu J* (2021) The oleaginous astaxanthin-producing alga Chromochloris zofingiensis: potential from production to an emerging model for studying lipid metabolism and carotenogenesis. Biotechnology for Biofuels 14: 119.

9. Zhang Y#, Pan Y#, Ding W, Hu H, Liu J* (2021) Lipid production is more than doubled by manipulating a diacylglycerol acyltransferase in algae. GCB Bioenergy, 13: 185–200

10. Shi Y, Liu M, Ding W, Liu J* (2020) Novel insights into phosphorus deprivation-boosted lipid synthesis in the marine alga Nannochloropsis oceanica without compromising biomass production. Journal of Agricultural and Food Chemistry, 68: 11488–11502.

11. Zhang Y, Ye Y, Ding W, Mao X, Li Y, Gerken H, Liu J* (2020). Astaxanthin is ketolated from zeaxanthin independent of fatty acid synthesis in Chromochloris zofingiensis. Plant Physiology 183: 883-897

12. Kou Y, Liu M, Sun P, Dong Z, Liu J* (2020) High light boosts salinity stress-induced biosynthesis of astaxanthin and lipids in the green alga Chromochloris zofingiensis. Algal Research 50: 101976

13. Mao X#, Zhang Y#, Wang X#, Liu J* (2020) Novel insights into salinity-induced lipogenesis and carotenogenesis in the oleaginous astaxanthin-producing alga Chromochloris zofingiensis: a multi-omics study. Biotechnology for Biofuels,13: 73

14. Wu T, Fu Y, Shi Y, Li Y, Kou Y, Mao X, Liu J* (2020) Functional Characterization of Long-Chain Acyl-CoA Synthetase Gene Family from the Oleaginous Alga Chromochloris zofingiensis. Journal of Agricultural and Food Chemistry, 68: 4473-4484

15. Zhang Y, Shi M, Mao X, Kou Y, Liu J* (2019) Time-resolved carotenoid profiling and transcriptomic analysis reveal mechanism of carotenogenesis for astaxanthin synthesis in the oleaginous green alga Chromochloris zofingiensis. Biotechnology for Biofuels, 12:287

16. Sun Z, Wang X, Liu J* (2019) Screening of Isochrysis strains for simultaneous production of docosahexaenoic acid and fucoxanthin. Algal Research, 41: 101545

17. Wang X, Wei H, Mao X, Liu J* (2019) Proteomics analysis of lipid droplets from the oleaginous alga Chromochloris zofingiensis reveals novel proteins for lipid metabolism. Genomics, Proteomics & Bioinformatics, 17: 260-272

18. Sun Z, Zhang Y, Sun L-p, Liu J* (2019) Light Elicits Astaxanthin Biosynthesis and Accumulation in the Fermented Ultrahigh-Density Chlorella zofinginesis. Journal of Agricultural and Food Chemistry, 67: 5579–5586

19. Liu J*, Sun Z, Mao X, Gerken H, Wang X, Yang W (2019) Multi-omics analysis reveals distinct mechanism of oleaginousness in the emerging model alga Chromochloris zofingiensis. Plant Journal, 2019;98:1060–1077

20. Mao X, Wu T, Kou Y, Shi Y, Zhang Y, Liu J* (2019) Characterization of type I and II diacylglycerol acyltransferases from the emerging model alga Chlorella zofingiensis reveals their functional complementarity and engineering potential. Biotechnology for Biofuels, 12: 28

21. Shi M, Wei H, Chen Q, Wang X, Zhou W, Liu J* (2019) Exploring an isolate of the oleaginous alga Micractinium inermum for lipid production: molecular characterization and physiochemical analysis under multiple growth conditions. Journal of Applied Phycology, 31, 1035-1046

22. Cheng K, Xu Y, Yang C, Ouellette L, Niu L, Zhou X, Chu L, Zhuang F, Liu J, Wu H, Charron JB, Luo M (2019) Histone tales: lysine methylation, a protagonist in Arabidopsis development. Journal of Experimental Botany, 71: 793-807

23. Sun Z, Wei H, Zhou Z-g, Ashokkumar M, Liu J* (2018) Screening of Isochrysis Strains and Utilization of a Two-Stage Outdoor Cultivation Strategy for Algal Biomass and Lipid Production. Applied Biochemistry and Biotechnology, 185: 1100–1117

24. Chen J, Leng L, Ye C, Lu Q, Addy M, Wang J, Liu J, Chen P, Ruan R, Zhou W (2018) A comparative study between fungal pellet- and spore-assisted microalgae harvesting methods for algae bioflocculation. Bioresource Technology, 259: 181-190

25. Yang C, Shen W, Chen H, Chu L, Xu Y, Zhou X, Liu C, Chen C, Zeng J, Liu J, Li Q, Gao C, Charron J-B, Luo M (2018) Characterization and subcellular localization of histone deacetylases and their roles in response to abiotic stresses in soybean. BMC Plant Biology 18: 226

26. Ma X, Liu B, Yang B, Guo B, Liu J*, Chen F* (2018) Physiochemical and gene expression analyses reveal differential responses of the marine oleaginous alga Nannochloropsis salina under different lipid-induction conditions. Journal of Applied Phycology, 30: 909-919

27. Xin Y#, Lu Y#, Lee Y#, Wei L, Jia J, Wang Q, Wang D, Bai F, Hu H, Hu Q, Liu J*, Li Y*, Xu J* (2017) Producing designer oils in industrial microalgae by rational modulation of co-evolving type-2 diacylglycerol acyltransferases. Molecular Plant, 10: 1523-1539

28. Sun Z, Chen Y, Mao X, Liu J* (2017) Physiological and biochemical changes reveal differential patterns of docosahexaenoic acid partitioning in two marine algal strains of Isochrysis. Marine Drugs, 15: 357

29. Wei HH, Shi Y, Ma XN, Pan Y, Hu HH, Li YT, Luo M, Gerken H, Liu J* (2017) A type I diacylglycerol acyltransferase modulates triacylglycerol biosynthesis and fatty acid composition in the oleaginous microalga Nannochloropsis oceanica. Biotechnology for Biofules, 10: 174

30. Yang B, Liu J*, Ma X, Guo B, Liu B, Wu T, Jiang Y, Chen F* (2017) Genetic engineering of the Calvin cycle toward enhanced photosynthetic CO2 fixation in microalgae. Biotechnology for Biofules, 10: 229 (Featured article)

31. Ma X, Yao L, Yang B, Lee Y, Chen F*, Liu J* (2017) RNAi-mediated silencing of a pyruvate dehydrogenase kinase enhances triacylglycerol biosynthesis in the oleaginous marine alga Nannochloropsis salina. Scientific Reports, 7: 11485

32. Zhou WG*, Wang JH, Chen P, Ji C, Kang Q, Lu B, Li K, Liu J*, Ruan R (2017) Bio-mitigation of carbon dioxide using microalgal systems: advances and Perspectives. Renewable Sustainable Energy Reviews. 76: 1163-1175

33. Liu J*, Lee Y, Mao X, Li Y* (2017) A simple and reproducible non-radiolabeled in vitro assay for recombinant acyltransferases involved in triacylglycerol biosynthesis. Journal of Applied Phycology, 29: 323-333

34. Liu J, Han D, Yoon K, Hu Q, Li Y (2016) Characterization of diacylglycerol acyltransferases in Chlamydomonas reinhardtii: Substrate specificity and their role in triacylglycerol biosynthesis. Plant Journal, 86: 3-19 (Cover, Featured article)

35. Liu J*, Mao X, Zhou W, Guarnieri M (2016) Simultaneous production of triacylglyerol and high-value carotenoids by the astaxanthin-producing oleaginous green microalga Chlorella zofingiensis. Bioresource Technology, 214: 319-327

36. Zhang Z, Sun D, Mao X, Liu J*, Chen F* (2016) The crosstalk between astaxanthin, fatty acids and reactive oxygen species in heterotrophic Chlorella zofingiensis. Algal Research, 19: 178-183

37. Yang B, Liu J*, Jiang Y, Chen F* (2016) Chlorella species as hosts for genetic engineering and expression of recombinant proteins: Progress, challenge and perspective. Biotechnology Journal, 11: 1244-1261 (Cover article)

38. Guo B, Liu B, Yang B, Sun P, Lu X, Liu J*, Chen F* (2016) Screening of diatom strains and characterization of Cyclotella cryptica as a potential fucoxanthin producer. Marine Drugs, 14, 125

39. Ma X, Chen T, Yang B, Liu J*, Chen F* (2016) Lipid Production from Nannochloropsis. Marine Drugs, 14: 61

40. Ma X, Liu J*, Liu B, Chen T, Jiang Y, Chen F* (2016) Physiological and biochemical changes reveal stress-associated photosynthetic carbon partitioning into triacylglycerol in the oleaginous marine alga Nannochloropsis oculata. Algal Research16:28-35

41. Chen T#, Liu J#, Guo B, Ma X, Sun P, Liu B, Chen F (2015). Light-mediated lipid reduction of Chlorella zofingiensis cultured with glucose through shifting carbon flux from lipid to starch. Scientific Reports, 5:14936

42. Sun Z, Zhou Z, Gerken H, Chen F, Liu J* (2015) Screening and characterization of oleaginous Chlorella strains and exploration of photoautotrophic Chlorella protothecoides for oil production. Bioresource Technology, 184, 53-62