李方廷
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李方廷
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论文成果
Dynamically modeling the effective range of IL-2 dosage in the treatment of systemic lupus erythematosus
发布时间：2023-06-20点击次数：
影响因子：
0.0
DOI码：
10.1016/j.isci.2022.104911
发表刊物：
iScience
摘要：
Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease characterized by an overactive immune response to self-antigen. The overactivation of CD4+ Foxp3− conventional T cells (Tcons) and the inactivation of CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) play important roles in the progression of SLE. Clinical trials showed that low-dose interleukin-2 (IL-2) is effective in treating SLE. Here, we developed a mathematical model involving Tcons, Tregs, natural killer (NK) cells, and IL-2 to simulate the dynamic processes involved in the treatment of SLE. We found an effective range of IL-2 dosage defined by the Tcon/Treg ratio in SLE treatment, termed the IL-2 dosage therapeutic window (IDTW). Our results showed that high levels of self-antigen result in a narrow IDTW and high post-treatment Tcon/Treg ratio. Furthermore, we proposed a classification method based on the ratio of pre-treatment Treg to CD4+ T cells to predict the treatment outcome of SLE patients.
论文类型：
期刊论文
文献类型：
J
是否译文：
否
发表时间：
2022-09-16
收录刊物：
SCI