30 nm染色质结构不仅是染色质包装过程中承上启下的关键，也在诸如发育、癌症等DNA相关的生理和病理活动中起了重要的调控功能（Cell 177: 1, 2019）。由于缺乏系统的、合适的研究手段，细胞内30 nm染色质高级结构一直是现代生物物理学和分子生物学领域面临的最大挑战之一。2014年，细胞外30 nm染色质结构由中国科学家李国红利用冷冻电镜首次得到了解析（Science 344: 376, 2014）。然而，细胞核内30 nm染色质纤维的精细结构，到目前为止仍然异常困难。
辐射瞬时诱导的DNA片段图谱包含有胞内细胞核30 nm结构的所有信息。因此，我们在已有多年研究辐射生物物理模型的基础上，通过和李国红老师课题组合作，着手建立基于实验和辐射生物物理模型的系统解析平台，解析细胞核内30 nm染色质结构在各种生理/病理活动中的动态变化。
组内已发表的相关代表研究论文：
Wenzong Ma, Chenyang Gu, Lin Ma, Caoqi Fan, Chao Zhang, Yujie Sun, Cheng Li*, Gen Yang*, Mixed secondary chromatin structure revealed by modeling radiation-induced DNA fragment length distribution, Science China Life Sciences, doi.org/10.1007/s11427-019-1638-6, 2020.
Wenzong Ma, Xudong Wang, Weihao Liu, Huan Ma, Yue Su, Yuanyou Yang, Ning Liu, Yugang Wang and Gen Yang*. A Theoretical Model for Predicting and Optimizing in vitro Screening of Potential Targeted Alpha Therapy Drugs. Radiation Research 191: 475-482, 2019.
Ying Liang, Qibin Fu, Xudong Wang, Feng Liu, Gen Yang*, Chunxiong Luo, Qi Ouyang and Yugang Wang. Relative biological effectiveness for photons: implication of complex DNA double-strand breaks as critical lesions. Physics in Medicine and Biology 62(6): 2153-2175; 2017.
Weikang Wang, Yi Quan, Qibin Fu, Yu Liu, Ying Liang, Jingwen Wu, Gen Yang*, Chunxiong Luo, Qi Ouyang, and Yugang Wang. Dynamics between cancer cell subpopulations reveals a model coordinating with both hierarchical and stochastic concepts. PLOS One 9(1): e84654; 2014.
Tao Mei, Gen Yang, Weikang Wang, Yugang Wang, Lijun Wu. A computational model for low-dose radiation induced cellular transformation by different radiation quantity. International Journal of Low Radiation 8(2): 135 - 147; 2011.