近期论文

Ø  Quantitative biology of yeast cell cycle

•        Critical slowing down and attractive manifold: a mechanism for dynamic robustness in yeast cell-cycle process. Physical Review E (2020)

•        Stochasticity triggers activation of the S-phase checkpoint pathway in budding yeast. Physical Review X (2021)

•        The multiple activations in budding yeast S-phase checkpoint are Poisson processes, PNAS Nexus（2023）2: gad342, https://doi.org/10.1093/pnasnexus/pgad342.

Ø  Nonequilibrium states of living cell

•        Phosphorylation energy and nonlinear kinetics as key determinants for G2/M transition in fission yeast cell cycle. arXiv:1610.09637. (Submitted to PNAS) .

•        Positive and reverse mitotic wave under different phosphorylation energy (Under prepare)

•        ATP hydrolysis kinetics and thermodynamics as determinants of calcium oscillation in pancreatic β cells.Phys. Rev. Research (2022) 4, 043142. https://doi.org/10.1103/PhysRevResearch.4.043142

Ø  Modeling immune system

•        A multicompartment mathematical model based on host immunity for dissecting COVID-19 heterogeneity. Heliyon (2022) 8(5) e09488.

•        Dynamically modeling the effective range of IL-2 dosage in the treatment of systemic lupus erythematosus. iScience. (2022) 25(9):104911.

 •     Dynamical modelling of viral infection and cooperative immune protection in COVID-19 patients. PLoS Comput. Biol. (2023) 19(9): e1011383.  https://doi.org/10.1371/journal.pcbi.1011383.

研究方向

酵母基因调控网络的定量生物学研究。

活细胞体系的非平衡稳态研究。

免疫系统的定量生物学研究。